This system is designed to do extracellular electrophysiology recordings and photometry detection at a single-cell resolution in a head-fixed configuration. Its optical sensitivity allows detection of standard fluorophores (GFP, mCherry, quantum dot, etc.) or functional fluorophores (GCaMP, Oregon Green, FURA-2, etc).
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This system is designed to do extracellular electrophysiology recordings and photometry detection at a single-cell resolution in a head-fixed configuration. Its optical sensitivity allows detection of standard fluorophores (GFP, mCherry, quantum dot, etc.) or functional fluorophores (GCaMP, Oregon Green, FURA-2, etc). Extracellular electrophysiology is possible by filling the fiber probe hollow core with an electrolyte solution to get an electrode impedance in the range of 1 to 20 M, allowing a single-unit or multi-unit spikes detection.
This system includes specifically:
- Fiber Photometry Console
- Connectorized Fluorescence Mini Cube (single or multiple wavelengths with appropriate filters)
- Photosensor Module (1 or 2x)
- Power Supply for PMT Module (1 or 2x)
- Laser Diode Fiber Light Sources (1 or 2x)
- Single-cell Opto-electric Probe Holder
- Clamp for Single-cell Opto-electric Probe Holder
- Single-cell Opto-electric Probe Adapter
- Single-cell Opto-electric Probe Interconnect Wire (5x)
- Single-cell Opto-electric Probe Tips (20x)
- Extracellular Electrophysiology Recording System (under development)
- All electrical cables and optical patch cords
The Single-cell Recording Opto-electric Probe Holder consists of a fiber-optic patch cord in a rigid tubing. It offers an appropriate optical connection between the probe core in the Single-cell Opto-electric Probe Adapter and the light module.
A Single-cell Recording Opto-electric Probe Tip is a piece of dual core optical fiber with a 500 µm optical core and a 250 µm hollow core for electrolyte filling with one end pulled and cut to a 10 µm diameter tip as illustrated above.
This is a more compact alternative to combination of a Connectorized Laser Diode Module and a Laser Diode Module Driver with 2 channels.
This FPGA based data acquisition unit synchronizes the output control and the acquisition of the input data. This device seamlessly integrates with Doric Neuroscience Studio, which provides the user-interface for multi-channel photometry experiments.
The link between the Single-cell Opto-electric Probe Holder and the Single-cell Opto-electric Probe Tip is assured by the Single-cell Opto-electric Probe Adapter. This junction component maintains and aligns the two optical cores together allowing a maximum amount of light to be guided towards the tip.
The Single-cell Opto-electric Interconnect Wire makes the connection between the electrolyte solution within the optical fiber hollow core and the electrophysiology system.